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The most crucial route of elimination is by using the urine where the elimination accounts for 70-80% of clearance of the drug . Around two thirds with the administered dose is excreted by means of the urine, generally as glucuronidated and hydroxylated types of aceclofenac . About 20% in the dose is excreted into feces . Pregnancy & Breastfeeding use

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The proposed mechanism is inhibition of CYP450 3A4-mediated 1st-move metabolism within the gut wall by certain compounds present in grapefruit.

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Renal insufficiency: There is no proof which the dosage of aceclofenac has to be modified in people with gentle renal impairment.